AKT1 Substrate 1 (Proline-Rich) (AKT1S1) Peptide
AKT1S1
Reactivité: Humain
Hôte: Synthetic
BP, WB
N° du produit ABIN973083
Aperçu rapide pour AKT1 Substrate 1 (Proline-Rich) (AKT1S1) Peptide (ABIN973083)
Antigène
PRAS40 (AKT1S1)
(AKT1 Substrate 1 (Proline-Rich) (AKT1S1))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-AKT1S1 antibody (Catalog #: ARP48061_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- PRAS40 (AKT1S1) (AKT1 Substrate 1 (Proline-Rich) (AKT1S1))
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Sujet
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AKT1S1 may play an important role in phosphatidylinositol 3-kinase (PI3K)-AKT1 survival signaling. It is the substrate for AKT1 phosphorylation, but can also be activated by AKT1-independent mechanisms. Its role in survival signaling pathways may be modulated by oxidative stress. AKT1S1 may also play a role in nerve growth factor-mediated neuroprotection.AKT1S1 is a proline-rich substrate of AKT (MIM 164730) that binds 14-3-3 protein (see YWHAH, MIM 113508) when phosphorylated (Kovacina et al., 2003 [PubMed 12524439]).[supplied by OMIM].
Alias Symbols: Lobe, MGC2865, PRAS40
Protein Interaction Partner: AKT1,AKT2,EIF6,MTOR,TCEA2,YWHAG,EIF6,TCEA2
Protein Size: 256 -
Poids moléculaire
- 27 kDa
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ID gène
- 84335
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NCBI Accession
- NM_032375, NP_115751
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UniProt
- Q96B36
Antigène
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